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當(dāng)前位置: 首頁(yè) » 食品資訊 » 外訊導(dǎo)讀 » 歐盟評(píng)估骨化二醇一水合物作為新型食品的安全性

歐盟評(píng)估骨化二醇一水合物作為新型食品的安全性

放大字體  縮小字體 時(shí)間:2021-07-02 10:03 來(lái)源:食品伙伴網(wǎng) 作者: 澤夕   
核心提示:2021年7月1日,據(jù)歐盟食品安全局(EFSA)消息,歐盟營(yíng)養(yǎng)、新型食品和食物過(guò)敏原(NDA)研究小組就通過(guò)化學(xué)合成生產(chǎn)的骨化二醇一水合物(calcidiol monohydrate )作為新型食品的安全性發(fā)表科學(xué)意見(jiàn)。
   食品伙伴網(wǎng)訊  2021年7月1日,據(jù)歐盟食品安全局EFSA)消息,歐盟營(yíng)養(yǎng)、新型食品和食物過(guò)敏原(NDA)研究小組就通過(guò)化學(xué)合成生產(chǎn)的骨化二醇一水合物(calcidiol monohydrate )作為新型食品的安全性發(fā)表科學(xué)意見(jiàn)。
 
  經(jīng)過(guò)評(píng)估,專家小組得出結(jié)論,在提議的使用條件下,骨化二醇一水合物作為新型食品對(duì)大于11歲的個(gè)人(包括孕婦和哺乳期婦女)是安全的。小組無(wú)法就骨化二醇一水合物對(duì)兒童(3-10歲)的安全性得出結(jié)論。部分原文報(bào)道如下:
 
  Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of calcidiol monohydrate as a novel food (NF) pursuant to Regulation (EU) 2015/2283, including its bioavailability as a metabolite of vitamin D3 when added for nutritional purposes to food supplements. The NF is produced chemically. It is proposed in food supplements up to 10?μg/day for individuals ≥ 11 years of age, including pregnant and lactating women and up to 5?μg/day in 3- to 10-year-old children. The production process, composition, specifications and stability of the NF do not raise safety concerns. Animal and human data indicate efficient absorption. The NF contains a fraction of nanoparticles, which are fat soluble and unlikely to reach systemic distribution. There are no concerns regarding genotoxicity. Human adult studies do not raise safety concerns. Combined intake estimates of calcidiol from the NF and calcidiol and vitamin D from the diet were below the tolerable upper intake level (UL) for vitamin D for subjects above 11 years of age. The achieved mean serum 25(OH)D concentration in adults supplemented with 10 μg NF per day remained below 200 nmol/L. The Panel concludes that the NF is safe under the proposed conditions of use and use levels for individuals ≥ 11 years old, including pregnant and lactating women. The applicant did not provide data on the bioavailability and safety of the NF in children. The combined intake estimation in children (3–10 years) is close to the UL for vitamin D. Therefore, the Panel could not conclude on the safety of consumption of the NF in children (3–10 years) at the proposed daily intake. The NF is a bioavailable source of the biologically active metabolite of vitamin D, i.e. 1,25-dihydroxyvitamin D.
 
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日期:2021-07-02
 
 
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