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當前位置: 首頁 » 食品資訊 » 外訊導讀 » 歐盟評估轉基因米曲霉菌株NZYM-PP生產(chǎn)的磷脂酶A1的安全性

歐盟評估轉基因米曲霉菌株NZYM-PP生產(chǎn)的磷脂酶A1的安全性

放大字體  縮小字體 時間:2023-02-28 11:03 來源:食品伙伴網(wǎng) 作者: 澤夕   
核心提示:2023年2月26日,歐盟食品安全局就一種食品酶磷脂酶A1(phospholipase A1)的安全性評價發(fā)布意見。
   食品伙伴網(wǎng)訊  2023年2月26日,歐盟食品安全局就一種食品酶磷脂酶A1(phospholipase A1)的安全性評價發(fā)布意見。
 
  據(jù)了解,這種食品酶是由轉基因米曲霉菌株NZYM-PP生產(chǎn)的,旨在用于奶酪生產(chǎn)中的牛奶加工。
 
  經(jīng)過評估,專家小組認為,在預期的使用條件下,不能排除飲食暴露引起過敏反應的風險,但這種情況發(fā)生的可能性很低。該小組得出結論,這種食品酶在預期使用條件下不會引起安全問題。部分原文報道如下:
 
  The food enzyme phospholipase A1 (phosphatidylcholine 1-acylhydrolase; EC 3.1.1.32) is produced with the genetically modified Aspergillus oryzae strain NZYM-PP by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The food enzyme was considered free from viable cells of the production organism and its DNA. It is intended to be used in milk processing for cheese production. Dietary exposure to the food enzyme–total organic solids (TOS) was estimated to be up to 0.012 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 575.1 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 47,925. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no matches were found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is low. The Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
 
  本文由食品伙伴網(wǎng)食品資訊中心編輯,有任何疑問,請聯(lián)系news@foodmate.net。
日期:2023-02-28
 
 
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