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當(dāng)前位置: 首頁 » 食品資訊 » 外訊導(dǎo)讀 » 歐盟評(píng)估一種轉(zhuǎn)基因地衣芽孢桿菌生產(chǎn)的α-淀粉酶的安全性

歐盟評(píng)估一種轉(zhuǎn)基因地衣芽孢桿菌生產(chǎn)的α-淀粉酶的安全性

放大字體  縮小字體 時(shí)間:2020-11-18 13:57 來源:食品伙伴網(wǎng) 作者: 澤夕   
核心提示:2020年11月13日,歐盟食品安全局就一種食品酶α-淀粉酶(α‐amylase)的安全性評(píng)價(jià)發(fā)布意見。
   食品伙伴網(wǎng)訊  2020年11月13日,歐盟食品安全局就一種食品酶α-淀粉酶(α‐amylase)的安全性評(píng)價(jià)發(fā)布意見。
 
  據(jù)了解,這種食品酶是由轉(zhuǎn)基因地衣芽孢桿菌(Bacillus licheniformis)菌株 DP‐Dzb45生產(chǎn)的,旨在用于釀造過程和蒸餾酒的生產(chǎn)中。
 
  經(jīng)過評(píng)估,專家小組認(rèn)為,在預(yù)期的使用條件下,生產(chǎn)蒸餾酒可以排除過敏性致敏和誘發(fā)反應(yīng)的風(fēng)險(xiǎn),但在釀造中使用該酶時(shí)則不能排除。根據(jù)提供的數(shù)據(jù),小組得出結(jié)論,該食品酶在預(yù)期的使用條件下不會(huì)引起安全隱患。部分原文報(bào)道如下:
 
  The food enzyme α‐amylase (1,4‐α‐D‐glucan glucanohydrolase; EC 3.2.1.1) is produced with the genetically modified Bacillus licheniformis strain DP‐Dzb45 by Danisco US Inc. The production strain of the food enzyme contains multiple copies of an antimicrobial resistance gene. However, based on the absence of viable cells and DNA from the production organism in the food enzyme, this was not considered to be a risk. The α‐amylase is intended to be used in brewing processes and distilled alcohol production. Since residual amounts of the food enzyme are removed by distillation, no dietary exposure was calculated for this intended use. based on the maximum use levels recommended for the brewing processes and individual data from the EFSA Comprehensive European Food Consumption Database, dietary exposure to the food enzyme–total organic solids (TOS) was estimated to be up to 0.138 mg TOS/kg body weight per day in European populations. Toxicological tests with the food enzyme indicated that there was no concern with respect to genotoxicity or systemic toxicity. A no observed adverse effect level was identified in rats, which, compared with the dietary exposure, results in a margin of exposure of at least 484. Similarity of the amino acid sequence to those of known allergens was searched and one match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions can be excluded in distilled alcohol production but cannot be excluded when the enzyme is used in brewing. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
 
  本文由食品伙伴網(wǎng)食品資訊中心編輯,供網(wǎng)友參考,歡迎轉(zhuǎn)載,轉(zhuǎn)載請(qǐng)注明出處!有任何疑問,請(qǐng)聯(lián)系news@foodmate.net。
日期:2020-11-18
 
 
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