食品伙伴網(wǎng)訊  據(jù)歐盟食品安全局（EFSA）消息，歐盟食品安全局食品添加劑和營養(yǎng)源專家組（ANS）重新評估了脂肪酸丙二醇酯（propane‐1,2‐diol esters of fatty acids，E477）作為食品添加劑的安全性。

 

　　通過評估，歐盟專家小組得出結(jié)論認(rèn)為，脂肪酸丙二醇酯在目前的授權(quán)使用水平中不存在安全問題，建議作為食品添加劑每日最大攝入量（ADI）為80 mg/kg bw。

 

　　部分原文報道如下：

 

　　The EFSA Panel on Food Additives and Flavourings （FAF） provides a scientific opinion re‐evaluating the safety of propane‐1,2‐diol esters of fatty acids （E 477） when used as a food additive. The Scientific Committee on Food （SCF） in 1978 endorsed the acceptable daily intake （ADI） of 25 mg/kg body weight （bw） per day, expressed as propane‐1,2‐diol, established by the Joint FAO/WHO Expert Committee on Food Additives （JECFA） in 1974. No adverse effects were observed in short‐term studies in rats and dogs at the highest doses tested. The Panel considered that E 477 did not raise a concern for genotoxicity. No chronic toxicity, carcinogenicity, reproductive and developmental toxicity studies with propane‐1,2‐diol esters of fatty acids were available to the Panel. The Panel considered that any potential adverse effect of propane‐1,2‐diol ester of fatty acids would be due to propane‐1,2‐diol, previously re‐evaluated as a food additive and for which an ADI of 25 mg/kg bw per day was established. Considering the overall metabolic and toxicity database, the Panel confirmed the previously established ADI for propane‐1,2‐diol esters of fatty acids （E 477） of 25 mg/kg bw per day expressed as propane 1,2 diol. This corresponds to an ADI for E 477 of 80 mg/kg bw per day, based on the concentration of free and bound propane‐1,2‐diol amounting to a maximum of 31% as laid down in the EU specification. The Panel concluded that there would not be a safety concern at the reported use levels for E 477 because exposure estimates from the refined non‐brand loyal scenario did not exceed the ADI for E 477 in any of the population groups. However, the Panel aims to explore the feasibility of establishing a group ADI for those food additives that result in an exposure to propane‐1,2‐diol, such as E 477, E 1520 and E 405. Additionally, the Panel will also consider performing a combined exposure assessment to propane‐1,2‐diol resulting from the use of these food additives. The Panel also recommended some modifications of the EU specifications for E 477.

 

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