食品伙伴網(wǎng)導(dǎo)讀，據(jù)美國營養(yǎng)成分網(wǎng)8月9日的消息稱，一項新的人體試驗數(shù)據(jù)表明，每日補充類胡蘿卜素蝦青素可改善輕度高脂血癥患者的高密度脂蛋白濃度。
先前有過動物實驗證明了蝦青素有利于增加高密度脂蛋白濃度降低甘油三酯濃度的功能，但這一性質(zhì)尚未被人體試驗所證明。本研究由來自日本Jikei大學(xué)Kashiwa醫(yī)院及富士化工的研究者，使用富士公司市售的蝦青素，對61名非肥胖型的均具有輕度甘油三酯水平偏高體質(zhì)的受試人員進(jìn)行了調(diào)查。這一研究結(jié)果發(fā)表在動脈粥樣硬化（Atherosclerosis）期刊上。
根據(jù)Frost＆Sullivan的數(shù)據(jù)，到2015年，蝦青素的全球市場將價值大約2億美元，其中大部分是用作色素，如加強鮭魚的粉紅色?，F(xiàn)有的研究也表明，蝦青素主要是對眼睛和皮膚的健康有益，同時也有利于關(guān)節(jié)和中樞神經(jīng)的健康，據(jù)說其抗氧化能力是維生素E的500倍。大部分蝦青素是來自于藻類，夏威夷紅藻，并且在一些常見的食用魚類及甲殼類動物中也很常見，這就是它們身上顯示出粉紅色的原因。
研究者把受試者隨機分為四組，每組每日攝入不同量的蝦青素（0、6、12、18mg），進(jìn)行了12周的研究。在研究結(jié)束時，最高攝入劑量的受試者血液中甘油三酯說平減少了24-25%。此外，中度攝入劑量（每天6mg及12mg）的受試者血液中的高密度脂蛋白的則分別上升了10%和15%。在攝入量高的2組中，脂聯(lián)素水平也有了顯著的上升，12mg的組別是上升超過了20%，而18mg的則上升了15-20%。
研究人員稱，目前的研究并未對其具體的機制進(jìn)行探討，而且這些也需要大量的臨床試驗來確認(rèn)這種蝦青素的益處。
原文報道：Astaxanthin’s heart benefits get human data support
By Stephen Daniells, 09-Aug-2010
Related topics: Research, Antioxidants, carotenoids, Cardiovascular health
Daily supplements of the carotenoid astaxanthin may improve HDL ‘good’ cholesterol levels in people with mildly abnormal blood lipid levels, suggests new data from a human trial.
Doses up to 18 milligrams per day for 12 weeks improved blood levels of HDL cholesterol, as well as adiponectin concentrations, a protein hormone linked to various metabolic processes, according to findings published in Atherosclerosis.
Researchers from Jikei University Kashiwa Hospital in Japan and Fuji Chemical Industry used Fuji’s commercially available AstaReal astaxanthin ingredient, and the trial involved 61 non-obese people with mildly elevated triglyceride levels.
According to the researchers, the potential benefits of astaxanthin with regards to HDL cholesterol and triglycerides have been demonstrated previously in animal studies, but supporting data from humans have been lacking.
“The present double-blind, placebo-controlled study could be the first to clearly demonstrate that the administration of astaxanthin at doses of 12 and 18 mg/day significantly decreased triglyceride and increased HDL-cholesterol and adiponectin in humans,” wrote the researchers, led by Jikei University’s Hiroshi Yoshida.
A rosy future for the pink pigment?
The global astaxanthin market is estimated to be worth about $200 million by 2015, most of which is used as a pigment to enhance the pink coloration of fish such as salmon. The human uses market is growing and estimated at about $35-60 million, according to 2008 data from Frost & Sullivan.
Its main health benefits are eye and skin health although it has also been linked to joint health and central nervous system health and is said to have an antioxidant payload 500 times that of vitamin E.
Most astaxanthin is derived from the algae, Haematococcus pluvialis, which is commonly consumed by fish and crustaceans and is responsible for their pink coloration.
Study details
Yoshida and his co-workers recruited mildly hyperlipidemic subjects (serum triglyceride levels between 120 and 200 mg per dl) with an average age of 44 to participate in their placebo-controlled 12-week study. The participants were randomly assigned to receive one of four doses of astaxanthin - 0, 6, 12, or 18 milligrams per day.
At the end of the study, participants receiving the two highest doses experienced significant reductions in their triglyceride levels, of 25 and 24 percent, respectively, compared to baseline. Furthermore, people receiving 6 or 12 mg per day experienced significant increases in their HDL-cholesterol levels of 10 and 15 percent, respectively.
Additionally, adiponectin levels increased in the two highest dose groups, with increases over 20 percent in the 12 mg per day group, and between 15 and 20 percent in the 18 percent group, added the researchers.
“Although the present study does not reveal the specific underlying mechanisms, astaxanthin may be expected to successfully treat impaired lipid metabolism and prevent atherosclerosis because of its possible therapeutic increase of HDL-cholesterol and adiponectin. However, well defined in vitro studies, long-term and large-scaled clinical trials will be needed to confirm such astaxanthin benefits,” concluded the researchers.
原文地址：http://www.nutraingredients-usa.com/Research/Astaxanthin-s-heart-benefits-get-human-data-support
Related topics: Research, Antioxidants, carotenoids, Cardiovascular health
Daily supplements of the carotenoid astaxanthin may improve HDL ‘good’ cholesterol levels in people with mildly abnormal blood lipid levels, suggests new data from a human trial.
Doses up to 18 milligrams per day for 12 weeks improved blood levels of HDL cholesterol, as well as adiponectin concentrations, a protein hormone linked to various metabolic processes, according to findings published in Atherosclerosis.
Researchers from Jikei University Kashiwa Hospital in Japan and Fuji Chemical Industry used Fuji’s commercially available AstaReal astaxanthin ingredient, and the trial involved 61 non-obese people with mildly elevated triglyceride levels.
According to the researchers, the potential benefits of astaxanthin with regards to HDL cholesterol and triglycerides have been demonstrated previously in animal studies, but supporting data from humans have been lacking.
“The present double-blind, placebo-controlled study could be the first to clearly demonstrate that the administration of astaxanthin at doses of 12 and 18 mg/day significantly decreased triglyceride and increased HDL-cholesterol and adiponectin in humans,” wrote the researchers, led by Jikei University’s Hiroshi Yoshida.
A rosy future for the pink pigment?
The global astaxanthin market is estimated to be worth about $200 million by 2015, most of which is used as a pigment to enhance the pink coloration of fish such as salmon. The human uses market is growing and estimated at about $35-60 million, according to 2008 data from Frost & Sullivan.
Its main health benefits are eye and skin health although it has also been linked to joint health and central nervous system health and is said to have an antioxidant payload 500 times that of vitamin E.
Most astaxanthin is derived from the algae, Haematococcus pluvialis, which is commonly consumed by fish and crustaceans and is responsible for their pink coloration.
Study details
Yoshida and his co-workers recruited mildly hyperlipidemic subjects (serum triglyceride levels between 120 and 200 mg per dl) with an average age of 44 to participate in their placebo-controlled 12-week study. The participants were randomly assigned to receive one of four doses of astaxanthin - 0, 6, 12, or 18 milligrams per day.
At the end of the study, participants receiving the two highest doses experienced significant reductions in their triglyceride levels, of 25 and 24 percent, respectively, compared to baseline. Furthermore, people receiving 6 or 12 mg per day experienced significant increases in their HDL-cholesterol levels of 10 and 15 percent, respectively.
Additionally, adiponectin levels increased in the two highest dose groups, with increases over 20 percent in the 12 mg per day group, and between 15 and 20 percent in the 18 percent group, added the researchers.
“Although the present study does not reveal the specific underlying mechanisms, astaxanthin may be expected to successfully treat impaired lipid metabolism and prevent atherosclerosis because of its possible therapeutic increase of HDL-cholesterol and adiponectin. However, well defined in vitro studies, long-term and large-scaled clinical trials will be needed to confirm such astaxanthin benefits,” concluded the researchers.
原文地址：http://www.nutraingredients-usa.com/Research/Astaxanthin-s-heart-benefits-get-human-data-support
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