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歐盟評估非轉(zhuǎn)基因塔賓曲霉菌株NL151生產(chǎn)的三酰甘油脂肪酶的安全性
日期:2024-10-11  來源:食品伙伴網(wǎng)
   食品伙伴網(wǎng)訊  2024年10月10日,歐盟食品安全局就一種食品酶三酰甘油脂肪酶(triacylglycerol lipase)的安全性評價發(fā)布意見。
  
  據(jù)了解,這種食品酶是由非轉(zhuǎn)基因塔賓曲霉菌株NL151生產(chǎn)的,旨在用于6種食品生產(chǎn)過程。
  
  經(jīng)過評估,專家小組認為,在預期的使用條件下,不能排除通過飲食接觸引起過敏反應(yīng)的風險,但這種情況發(fā)生的可能性很低。根據(jù)所提供的數(shù)據(jù),小組得出結(jié)論,該食品酶在預期的使用條件下不會引起安全問題。部分原文報道如下:
  
  The food enzyme triacylglycerol lipase (triacylglycerol acylhydrolase; EC 3.1.1.3) is produced with the non-genetically modified Aspergillus tubingensis strain NL151 by Shin Nihon Chemical Co., Ltd. The food enzyme was free from viable cells of the production organism. It is intended to be used in six food manufacturing processes. Dietary exposure was estimated to be up to 0.278 mg total organic solids (TOS)/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1669 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 6004. A search for homology of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that, the risk of allergic reactions upon dietary exposure cannot be excluded, but the likelihood is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.
  
  本文由食品伙伴網(wǎng)食品資訊中心編輯,供網(wǎng)友參考,有任何疑問,請聯(lián)系news@foodmate.net。
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