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歐盟評估非轉(zhuǎn)基因黑曲霉菌株DP-Azh100生產(chǎn)的葡聚糖1,4-α-葡萄糖苷酶的安全性
日期:2024-11-14  來源:食品伙伴網(wǎng)
   食品伙伴網(wǎng)訊  2024年11月13日,歐盟食品安全局就一種葡聚糖1,4-α-葡萄糖苷酶(glucan-1,4-α-glucosidase)的安全性評價發(fā)布意見。
  
  據(jù)了解,這種食品酶是由非轉(zhuǎn)基因黑曲霉菌株DP-Azh100生產(chǎn)的,旨在用于4種食品生產(chǎn)過程。
  
  經(jīng)過評估,專家小組認為,在預期的使用條件下,不能排除飲食暴露引起過敏反應的風險,但這種情況發(fā)生的可能性很低。根據(jù)所提供的數(shù)據(jù),評估小組得出結(jié)論,這種食品酶在預期使用條件下不會引起安全問題。部分原文報道如下:
  
  The food enzyme glucan-1,4-α-glucosidase (4-α-d-glucan glucohydrolase; EC 3.2.1.3) is produced with the non-genetically modified Aspergillus niger strain DP-Azh100 by Genencor International B.V. It was considered free from viable cells of the production organism. The food enzyme is intended to be used in four food manufacturing processes. Since residual amounts of total organic solids (TOS) are removed in two processes, dietary exposure was calculated only for the two remaining processes. It was estimated to be up to 1.390 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level at the highest dose tested of 1000 mg TOS/kg bw per day, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 719. A search for the homology of the amino acid sequence of the food enzyme to known allergens was made and one match to a respiratory allergen was found. Known sources of food allergens were used in the food enzyme manufacturing process. The Panel considered that the risk of allergic reactions upon dietary exposure to this food enzyme cannot be excluded, but the likelihood is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use. 
  
  本文由食品伙伴網(wǎng)食品資訊中心編輯,有任何疑問,請聯(lián)系news@foodmate.net。
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